Background:

AMP-activated protein kinase (AMPK) is an evolutionary conserved regulator of energy homeostasis and a promising drug target for the treatment of metabolic disorders. We have recently identified Transcription Factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, as a downstream target of AMPK in various cells.

 

The project:

The purpose of this project is to investigate the molecular mechanism responsible for the regulation of AMPK-induced TFEB control. To address this, we will use cell culture, western blotting, immunoprecipitation, cellular fractionation or siRNA-mediated gene silencing. https://cbmr.ku.dk/research/nutrient-and-metabolite-sensing/sakamoto-group/ We are looking for an ambitious and highly organized student interested in metabolic signaling.

 

Contact:

Group: Sakamoto Group

Florentina Negoita, Postdoc: florentina.negoita@sund.ku.dk 

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