Cardiac arrhythmias are a leading cause of death in the Western world, partly because the molecular causes are not well established.
New insights into causal mechanisms are becoming apparent from cancer patients treated with tyrosine kinase inhibitors who develop drug-dependent cardiac arrhythmias. It is, at present, unclear why the inhibitors used for anti-cancer treatment cause arrhythmia.
In this project you will investigate which signaling pathways cause these problematic effects of tyrosine kinase inhibitors in the heart. Your project is focused on fibroblasts isolated from hearts, and you will investigate which proteins a regulated in these cells in response to anti-cancer treatment. The project involves isolation of primary cardiac cells, biochemical assays to evaluate signaling events and cutting-edge proteomics approaches.
Your project will contribute to elucidating the molecular mechanisms that lead to cardiac arrhythmias of the cancer treatment with the ultimate goal of identifying novel targets for pharmaceutical intervention.